The COVID-19 pandemic has made us aware of the dangers of infectious diseases and the need to prevent and respond to infections in everyday life. Vessels are very vulnerable to the spread of infection because they are both isolated and closed, and maintaining operational continuity is very important for public vessels in carrying out public duties. In particular, the patrol ships are at a very high risk of secondary damage due to loss of operational continuity due to the spread of infection on board. In this study, the policies and literature of domestic and overseas cases related to infection prevention and response on ships were investigated and analyzed. The Korea Maritime Transportation Safety Authority (KOMSA) developed the ‘the Standard of Shipboard Infection Prevention (SIP)’ and certified public ships. An evaluation of the development of the standard was conducted to determine the applicability and objective effectiveness of the SIP for patrol ships. The recent declaration of the end of the COVID-19 pandemic by the World Health Organization (WHO) does not mean that humanity has become completely free from infectious diseases. When a new type of infectious disease occurs in the future, it is expected that the standard certification for the prevention and response of patrol ships on board will be a preemptive and effective countermeasure to prevent loss of operational continuity of patrol ships.